It will be the first meeting between the clubs in the Premier League with fans in attendance since September 2019, when the sides played out a 2-2 cracker at the Emirates.
That is where this match will be played following four meetings since either behind closed doors of friendlies, three of which were at Spurs’ stadium.
The Gunners welcome their closest rivals with the chance to move level on points if they come out victorious.
Since making a winning start to their top-flight campaign, Tottenham have lost their last two matches.
Conversely, Mikel Arteta’s men lost on their first three outings but have won their past pair of games.
Nuno Espirito Santo is under pressure to avoid another London derby defeat, with Spurs losing 3-0 to Chelsea last Sunday.
What time is Arsenal vs Tottenham?
The match kicks off at 4:30pm on Sunday, rounding out the weekend’s action.
Both teams come into the encounter having progressed in their third-round League Cup times in contrasting fashion.
Arsenal were visited by League One Wimbledon, who they swatted 3-0.
That was while Tottenham needed penalties to beat Wolverhampton Wanderers away from home.
Craig Pawson has been appointed the man in the middle for a match always bound to see bookings.
What do you think the score will be? Give us your prediction here.
Arsenal vs Tottenham TV channel and live stream
Sky Sports will be broadcasting the match, with coverage staring from 4pm following Southampton’s clash with Wolves at 2pm.
Channels Sky Sports Main Event and Sky Sports Premier League will be broadcasting the derby live, while Match of the Day 2 will start at 10:30pm for highlights.
Sky Sports customers can live stream the contest via the app using their mobile, tablet or computer devices.
Alternatively, a Sky Sports Day Pass from NowTV for £9.99.
What’s the team news?
The Gunners have a clean bill of health after an injury-hit start to the campaign.
Arteta will have Granit Xhaka available again following his three-match suspension for a red card he received when Manchester City thumped Arsenal 5-0 in August.
10 changes were made in midweek, with Thomas Partey the only Gunner to retain his place from the 1-0 win at Burnley last Saturday.
On the other hand, Spurs’ treatment room has gotten busier ahead of the affair.
Winger Steven Bergwijn is a doubt due to an ankle issue, while Lucas Moura picked up a knock during Tottenham’s Europa League group stage draw at Rennes last Thursday.
Ryan Sessegnon is also unlikely to feature through injury.
In last term’s two league meetings, each team picked up one win (the home side).
Prior to Arsenal’s win in March, the Gunners had gone five games without beating Tottenham.
Spurs won the pre-season friendly in August 1-0 thanks to Heung-Min Son’s late effort but have not claimed victory at the Emirates since November 2010.
Younes Kaboul completed a comeback with a strike in the 86th minute after Gareth Bale and Rafael van Der Vaart cancelled out early goals Samir Nasri and Marouane Chamakh.
Tottenham have since beaten Arsenal twice in their own back yard in the League Cup but the Gunners have managed to stop Spurs from taking all three points from their home ground in the Premier League on the last 10 occasions.
Here are the Grosvenor Sport odds (prices subject to change):