Varane was then spotted watching the rest of the contest from the comfort of the substitutes bench with an ice pack wrapped around his thigh.
United boss Ole Gunnar Solskjaer will be concerned by the manner in which his central defender picked up the injury, which was not a result of any kind of impact or collision with another player.
The 28-year-old pulled up as he was racing back towards his own goal to intercept a cross, his attempts to power through afterwards in vain as he could not carry on and was replaced just before the interval.
The Old Trafford faithful will not be pleased with the latest reports emerging from France over Varane’s fitness, with L’Equipe claiming the former Real Madrid star will need to be sidelined for a number of days to recover.
Varane’s first series of fitness tests have confirmed the defender sustained a strain to the right adductor muscle and is unlikely to be ready to take on Leicester at the King Power Stadium on Saturday.
Traditionally, grade one adductor tears will put a player out of action for around two weeks at a time.
United are planning on putting the defender through further tests to get a clearer picture of the severity of the injury and determine for just how long Varane could be unavailable.
The Frenchman only arrived back at United’s Carrington training base on Tuesday morning, where he will be assessed by the Red Devils medical team.
As a result, it is unlikely Solskjaer plays Varane against the Foxes this weekend and risk aggravating the injury further.
UEFA via Getty Images)
Maguire has not recovered from the calf injury in time to face his former side at the King Power Stadium.
The England international has made progress in his bid to return to full fitness, having taken part in light training but is yet to enjoy a full-contact session as of yet.
Solskjaer is likely to deploy a central defensive pairing of Victor Lindelof and Eric Bailly at the weekend, both players traditionally deputies for the crocked duo of Varane and Maguire.