Buzz stung his Newmarket Cesarewitch rivals amid another close battle for title rivals Oisin Murphy and Will Buick.
Murphy, who failed a breath test at the track on Friday, foiled Willie Mullins’ bid to win the Newmarket race four years on the trot.
Buzz, sent off at 8-1, had the edge over one of the Mullins team Burning Victory, with the pair a National Hunt distance clear of the third.
Murphy, forced to miss his rides 24 hours earlier, asked his mount to close on the Irish raider two furlongs from the finish.
Burning Victory was still in front for Buick passing the furlong pole, but the Nicky Henderson-trained Buzz had extra reserves and gained a length-and-half triumph.
“I shouldn’t be making mistakes like that yesterday. It is great to get some confidence back but I should know better,” Murphy said.
“I’m very sorry to everyone. I’m not faultless and I’ve got to do better.”
With just days to go until the championship is decided, Murphy holds a seven-winner lead following his Together For Racing International Cesarewitch victory.
It was a third win in the race for Henderson, readying his hurdlers and chasers for the upcoming jumps season.
“I think Nicky had planned this out from his last race over jumps last season so it was five months’ worth of planning,” Murphy added.
“He was very good and he travelled through them.
“The other horse kicked first and it is such a long way home here but he stays well and that is the key.”
Native Trial (5-6f) was one of three winners on the card for Buick in the Group 1 Darley Dewhurst Stakes.
The colt, 3-1 (from 4-1) with Coral for next year’s 2000 Guineas, was a comfortable two-length scorer.
“He’s got a lot of speed but showed a great attitude to win today,” Buick said.
“It’s a privilege to ride a colt of his calibre.”